Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase

Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase

Nitric oxide (NO) produced by mammalian nitric oxide synthases (mNOSs) is an important mediator in a variety of physiological functions. Crystal structures of mNOSs have shown strong conservation of the active‐site residue Val567 (numbering for rat neuronal NOS, nNOS). NOS‐like proteins have been id...

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Bibliographic Details
Main Authors: Inger K. Olsbu, Giorgio Zoppellaro, K. Kristoffer Andersson, Jean‐Luc Boucher, Hans‐Petter Hersleth
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:FEBS Open Bio
Subjects:
active‐site mutations
heme
nitric oxide
nitric oxide synthase
substrate analogues binding
UV‐visible spectroscopy
Online Access:https://doi.org/10.1002/2211-5463.12503

Internet

https://doi.org/10.1002/2211-5463.12503

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