Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation

Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation

The noradrenergic system is paramount for controlling pain and emotions. We aimed at understanding the descending noradrenergic modulatory mechanisms in joint inflammatory pain and its correlation with the diffuse noxious inhibitory controls (DNICs) and with the onset of anxiodepressive behaviours....

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Bibliographic Details
Main Authors: Raquel Pereira-Silva, José Tiago Costa-Pereira, Raquel Alonso, Paula Serrão, Isabel Martins, Fani L. Neto
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
chronic joint inflammatory pain
descending noradrenergic pain modulation
diffuse noxious inhibitory controls
anxiodepressive comorbidities
locus coeruleus
pERK1/2
Online Access:https://www.mdpi.com/1422-0067/21/8/2973

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https://www.mdpi.com/1422-0067/21/8/2973

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