Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling

Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling

Abstract Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of neurological and immunological effects throughout the central nervous system (CNS) and is associated with the etiology of affective and cognitive disorders. The cognate receptor for IL-1, Interleukin-1 Receptor...

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Main Authors: Daniel P. Nemeth, Xiaoyu Liu, Marianne C. Monet, Haichen Niu, Gabriella Maxey, Matt S. Schrier, Maria I. Smirnova, Samantha J. McGovern, Anu Herd, Damon J. DiSabato, Trey Floyd, Rohit R. Atluri, Alex C. Nusstein, Braedan Oliver, Kristina G. Witcher, Joshua St. Juste Ellis, Jasmine Yip, Andrew D. Crider, Daniel B. McKim, Paula A. Gajewski-Kurdziel, Jonathan P. Godbout, Qi Zhang, Randy D. Blakely, John F. Sheridan, Ning Quan
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03287-1

Internet

https://doi.org/10.1186/s12974-024-03287-1

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