Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits

Abstract Measuring allele-specific expression in interspecies hybrids is a powerful way to detect cis-regulatory changes underlying adaptation. However, it remains difficult to identify genes most likely to explain species-specific traits. Here, we outline a simple strategy that leverages population...

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Bibliographic Details
Main Authors: Alexander L. Starr, David Gokhman, Hunter B. Fraser
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-023-02846-8