A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics

A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics

Heritability estimates support the contribution of genetics and the environment to the etiology of Autism Spectrum Disorder (ASD), but a role for gene-environment interactions is insufficiently explored. Genes involved in detoxification pathways and physiological permeability barriers (e.g., blood-b...

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Bibliographic Details
Main Authors: João Xavier Santos, Célia Rasga, Ana Rita Marques, Hugo Martiniano, Muhammad Asif, Joana Vilela, Guiomar Oliveira, Lisete Sousa, Ana Nunes, Astrid M. Vicente
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
autism spectrum disorder
blood-brain barrier
detoxification
gene-environment interactions
placenta
xenobiotics exposure
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.862315/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.862315/full

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