The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression

The CREB1 inhibitor 666-15 maintains cartilage homeostasis and mitigates osteoarthritis progression

Aims: cAMP response element binding protein (CREB1) is involved in the progression of osteoarthritis (OA). However, available findings about the role of CREB1 in OA are inconsistent. 666-15 is a potent and selective CREB1 inhibitor, but its role in OA is unclear. This study aimed to investigate the...

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Bibliographic Details
Main Authors: Ying Wang, Zhimin Wu, Guoqiang Yan, Shan Li, Yanzhuo Zhang, Guangping Li, Chengai Wu
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2024-01-01
Series:Bone & Joint Research
Subjects:
creb1
666-15
cartilage homeostasis
osteoarthritis
osteoarthritis (oa)
chondrocytes
cartilage tissues
anterior cruciate ligament transection (aclt)
staining
articular cartilage tissue
apoptosis
subchondral bone
mouse model
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.131.BJR-2023-0016.R2

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.131.BJR-2023-0016.R2

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