Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells

Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells

Platelet factor 4 (CXCL4) is a chemokine abundantly stored in platelets. Upon injury and during atherosclerosis, CXCL4 is transported through the vessel wall where it modulates the function of vascular smooth muscle cells (VSMCs) by affecting proliferation, migration, gene expression and cytokine re...

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Bibliographic Details
Main Authors: Dawid M. Kaczor, Rafael Kramann, Tilman M. Hackeng, Leon J. Schurgers, Rory R. Koenen
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
CXCL4
CXCL4L1
smooth muscle cell
inflammation
artery
vascular remodeling
Online Access:https://www.mdpi.com/1422-0067/23/2/580

Internet

https://www.mdpi.com/1422-0067/23/2/580

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