The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-Cell Leukaemia

The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-Cell Leukaemia

We have previously shown that antibody-dependent cellular cytotoxicity (ADCC) cooperates with immunotoxin (IT)-mediated killing of human leukaemia cells in an severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic leukaemia (SCID-HSB-2 mice), but not in an equivalent...

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Bibliographic Details
Main Authors: David J. Flavell, Suzanne E. Holmes, Sarah L Warnes, Sopsamorn U. Flavell
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Biomedicines
Subjects:
immunotoxin
CD7
T-ALL
SCID mouse
TLR3 agonist
therapy
augmentation
Online Access:https://www.mdpi.com/2227-9059/7/1/13

Internet

https://www.mdpi.com/2227-9059/7/1/13

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