Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells

Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells

Mesodermal differentiation of induced pluripotent stem cells (iPSCs) in vitro and subsequent specification into mesodermal derivatives like chondrocytes is currently afflicted with a substantial cell loss that severely limits tissue yield. More knowledge on the key players regulating mesodermal diff...

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Bibliographic Details
Main Authors: Ursula Kreuser, Justyna Buchert, Alexandra Haase, Wiltrud Richter, Solvig Diederichs
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
induced pluripotent stem cells
cartilage
WNT/β-catenin
extracellular matrix
cell survival
aggregation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.581331/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.581331/full

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