Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease

Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease

Abstract Graft‐versus‐host disease (GVHD) is a major life‐threatening complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Inflammatory signaling pathways promote T‐cell activation and are involved in the pathogenesis of GVHD. Suppressor of cytokine signaling 1 (SOCS1) is...

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Bibliographic Details
Main Authors: Huidong Guo, Ruifeng Li, Ming Wang, Yingping Hou, Shuoshuo Liu, Ting Peng, Xiang‐Yu Zhao, Liming Lu, Yali Han, Yiming Shao, Ying‐Jun Chang, Cheng Li, Xiao‐Jun Huang
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
graft‐versus‐host disease (GVHD)
hematopoietic stem cell transplantation (HSCT)
multiomics
SOCS1
T cell tolerance
Online Access:https://doi.org/10.1002/advs.202200978

Internet

https://doi.org/10.1002/advs.202200978

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