Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

Abstract Background The Nucleoprotein (NP) is the most abundant and highly immunogenic protein in canine distemper virus (CDV), playing an important role in CDV viral replication and assembly. Results In this study, a specific monoclonal antibody, named C8, was produced against the NP protein C term...

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Bibliographic Details
Main Authors: Li Yi, Zhigang Cao, Mingwei Tong, Yuening Cheng, Yong Yang, Shuang Li, Jianke Wang, Peng Lin, Yaru Sun, Miao Zhang, Shipeng Cheng
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Virology Journal
Subjects:
Canine distemper virus
Nucleoprotein
Monoclonal antibody
B-cell epitope
Online Access:http://link.springer.com/article/10.1186/s12985-017-0858-6

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http://link.springer.com/article/10.1186/s12985-017-0858-6

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