Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel

Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel

Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute cardiac toxicity is not very clear. By using patch clamp techniques, we found that 0.05 mg/ml and 0.1 mg/ml of the aqueous crude extract of TWHF inhibit 21.4 ± 1.6% and 86...

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Bibliographic Details
Main Authors: Wei Zhao, Liping Xiao, Lanying Pan, Xianfu Ke, Yanting Zhang, Dian Zhong, Jianwei Xu, Fumin Cao, Liren Wu, Yuan Chen
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Heliyon
Subjects:
Dose-response relationship
Drug binding
Natural product
Toxicology
Cardiology
Pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019361870

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http://www.sciencedirect.com/science/article/pii/S2405844019361870

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