Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon

Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon

The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations, and f...

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Bibliographic Details
Main Authors: Guillem Pons, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Júlia Sansa-Girona, Lia García-Gilabert, Ainara Magdaleno, Miguel F. Segura, Josep Sánchez de Toledo, Soledad Gallego, Lucas Moreno, Josep Roma
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
cancer
gene amplifications
CRISPR-Cas9 screenings
gene dependencies
drug development
Online Access:https://www.mdpi.com/2072-6694/15/6/1636

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https://www.mdpi.com/2072-6694/15/6/1636

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