Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4

Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4

Abstract Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties. However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailability. To overcome these drawbacks of OBB, amorphous spray-dried powders (ASDs) of O...

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Bibliographic Details
Main Authors: Tingting Chen, Qingguo Li, Gaoxiang Ai, Ziwei Huang, Jun Liu, Lingfeng Zeng, Ziren Su, Yaoxing Dou
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Subjects:
Acute liver injury
Oxyberberine
Amorphous solid dispersions
Bioavailability
Online Access:https://doi.org/10.1038/s41598-024-65190-2

Internet

https://doi.org/10.1038/s41598-024-65190-2

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