GLI3 regulates muscle stem cell entry into GAlert and self-renewal
Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31695-5 |
| _version_ | 1811323551556304896 |
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| author | Caroline E. Brun Marie-Claude Sincennes Alexander Y. T. Lin Derek Hall William Jarassier Peter Feige Fabien Le Grand Michael A. Rudnicki |
| author_facet | Caroline E. Brun Marie-Claude Sincennes Alexander Y. T. Lin Derek Hall William Jarassier Peter Feige Fabien Le Grand Michael A. Rudnicki |
| author_sort | Caroline E. Brun |
| collection | DOAJ |
| description | Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells. |
| first_indexed | 2024-04-13T13:57:12Z |
| format | Article |
| id | doaj.art-029f9948098341d7a5dbb5349abfd906 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T13:57:12Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-029f9948098341d7a5dbb5349abfd9062022-12-22T02:44:08ZengNature PortfolioNature Communications2041-17232022-07-0113111410.1038/s41467-022-31695-5GLI3 regulates muscle stem cell entry into GAlert and self-renewalCaroline E. Brun0Marie-Claude Sincennes1Alexander Y. T. Lin2Derek Hall3William Jarassier4Peter Feige5Fabien Le Grand6Michael A. Rudnicki7Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteUniv Lyon, Univ Lyon 1, CNRS, INSERM, Pathophysiology and Genetics of Neuron and Muscle, UMR5261, U1315, Institut NeuroMyoGèneSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteUniv Lyon, Univ Lyon 1, CNRS, INSERM, Pathophysiology and Genetics of Neuron and Muscle, UMR5261, U1315, Institut NeuroMyoGèneSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstitutePrimary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.https://doi.org/10.1038/s41467-022-31695-5 |
| spellingShingle | Caroline E. Brun Marie-Claude Sincennes Alexander Y. T. Lin Derek Hall William Jarassier Peter Feige Fabien Le Grand Michael A. Rudnicki GLI3 regulates muscle stem cell entry into GAlert and self-renewal Nature Communications |
| title | GLI3 regulates muscle stem cell entry into GAlert and self-renewal |
| title_full | GLI3 regulates muscle stem cell entry into GAlert and self-renewal |
| title_fullStr | GLI3 regulates muscle stem cell entry into GAlert and self-renewal |
| title_full_unstemmed | GLI3 regulates muscle stem cell entry into GAlert and self-renewal |
| title_short | GLI3 regulates muscle stem cell entry into GAlert and self-renewal |
| title_sort | gli3 regulates muscle stem cell entry into galert and self renewal |
| url | https://doi.org/10.1038/s41467-022-31695-5 |
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