The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration

The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration

Breakdown of sphingomyelin as catalyzed by the activity of sphingomyelinases profoundly affects biophysical properties of cellular membranes which is particularly important with regard to compartmentalization of surface receptors and their signaling relay. As it is activated both upon TCR ligation a...

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Bibliographic Details
Main Authors: Lena Collenburg, Niklas Beyersdorf, Teresa Wiese, Christoph Arenz, Essa M. Saied, Katrin Anne Becker-Flegler, Sibylle Schneider-Schaulies, Elita Avota
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
neutral sphingomyelinase
T cell migration
ceramide
polarization
adhesion
LFA-1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01007/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01007/full

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