Carbamazepine regulates USP10 through miR-20a-5p to affect the deubiquitination of SKP2 and inhibit osteogenic differentiation

Carbamazepine regulates USP10 through miR-20a-5p to affect the deubiquitination of SKP2 and inhibit osteogenic differentiation

Abstract Background Antiepileptic drugs (AEDs) harm bone health and are significantly associated with osteoporosis development. In this study, we aimed to explore the mechanisms involved in carbamazepine (CBZ) and microRNA (miR)-20a-5p/ubiquitin-specific peptidase 10 (USP10)/S-phase kinase-associate...

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Bibliographic Details
Main Authors: Huan Wang, Ziye Liu, Dawei Niu, Haobo Li, Yaguang Han, Jinhui Peng, Qirong Qian
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Carbamazepine
miR-20a-5p
USP10
SKP2
Osteoporosis
Online Access:https://doi.org/10.1186/s13018-023-04169-7

Internet

https://doi.org/10.1186/s13018-023-04169-7

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