Inhibition of Interleukin-6-Induced Matrix Metalloproteinase-2 Expression and Invasive Ability of Lemon Peel Polyphenol Extract in Human Primary Colon Cancer Cells

Inhibition of Interleukin-6-Induced Matrix Metalloproteinase-2 Expression and Invasive Ability of Lemon Peel Polyphenol Extract in Human Primary Colon Cancer Cells

Among matrix metalloproteinases (MMPs), MMP-9/2 are key enzymes involved in the proteolysis of extracellular matrices in the inflammatory process and in cancer. Since MMP-9/2 expression levels, activity, and secretion is up-regulated during inflammation in response to pro-inflammatory cytokines, suc...

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Bibliographic Details
Main Authors: Valentina Pagliara, Marina De Rosa, Paola Di Donato, Rosarita Nasso, Antonio D’Errico, Francesca Cammarota, Annarita Poli, Mariorosario Masullo, Rosaria Arcone
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
matrix metalloproteinases (MMP)-2
interleukin-6
lemon (<i>Citrus limon</i>) peel extract
cell invasiveness
human primary colon cancer cells
Online Access:https://www.mdpi.com/1420-3049/26/23/7076

Internet

https://www.mdpi.com/1420-3049/26/23/7076

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