Global fungal-host interactome mapping identifies host targets of candidalysin

Global fungal-host interactome mapping identifies host targets of candidalysin

Abstract Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we performed a high-throughput enhanced yeast two-hybrid (HT-eY2H) screen to map the in...

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Main Authors: Tian-Yi Zhang, Yao-Qi Chen, Jing-Cong Tan, Jin-An Zhou, Wan-Ning Chen, Tong Jiang, Jin-Yin Zha, Xiang-Kang Zeng, Bo-Wen Li, Lu-Qi Wei, Yun Zou, Lu-Yao Zhang, Yue-Mei Hong, Xiu-Li Wang, Run-Ze Zhu, Wan-Xing Xu, Jing Xi, Qin-Qin Wang, Lei Pan, Jian Zhang, Yang Luan, Rui-Xin Zhu, Hui Wang, Changbin Chen, Ning-Ning Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46141-x

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https://doi.org/10.1038/s41467-024-46141-x

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