Towards Molecular Understanding of the Functional Role of UbiJ-UbiK<sub>2</sub> Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies

Towards Molecular Understanding of the Functional Role of UbiJ-UbiK<sub>2</sub> Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies

Ubiquinone (UQ) is a polyisoprenoid lipid found in the membranes of bacteria and eukaryotes. UQ has important roles, notably in respiratory metabolisms which sustain cellular bioenergetics. Most steps of UQ biosynthesis take place in the cytosol of <i>E. coli</i> within a multiprotein co...

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Bibliographic Details
Main Authors: Romain Launay, Elin Teppa, Carla Martins, Sophie S. Abby, Fabien Pierrel, Isabelle André, Jérémy Esque
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquinone
MD simulations
Alphafold2
molecular modelling
Martini 3 force field
peripheral membrane protein
Online Access:https://www.mdpi.com/1422-0067/23/18/10323

Internet

https://www.mdpi.com/1422-0067/23/18/10323

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