Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more information about FLU reduction in human liver, because this information has bee...

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Bibliographic Details
Main Authors: Vladimír Kubíček, Lenka Skálová, Adam Skarka, Věra Králová, Jana Holubová, Jana Štěpánková, Zdeněk Šubrt, Barbora Szotáková
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
flubendazole
carbonyl reduction
human
enzyme kinetics
stereospecificity
sex difference
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00600/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00600/full

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