Fusion with Promiscuous Gα<sub>16</sub> Subunit Reveals Signaling Bias at Muscarinic Receptors

Fusion with Promiscuous Gα<sub>16</sub> Subunit Reveals Signaling Bias at Muscarinic Receptors

A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream signaling and a lack of sufficiently sensitive and se...

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Bibliographic Details
Main Authors: Alena Randáková, Dominik Nelic, Martina Hochmalová, Pavel Zimčík, Mutale Jane Mulenga, John Boulos, Jan Jakubík
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
muscarinic receptors
signaling bias
fusion proteins
non-canonical signaling
Online Access:https://www.mdpi.com/1422-0067/22/18/10089

Internet

https://www.mdpi.com/1422-0067/22/18/10089

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