Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial

Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM). Several locoregional therapies are effective in the treatment of liver metastases, su...

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Bibliographic Details
Main Authors: T. M. L. Tong, M. K. van der Kooij, F. M. Speetjens, A. R. van Erkel, R. W. van der Meer, J. Lutjeboer, E. L. van Persijn van Meerten, C. H. Martini, R. W. M. Zoethout, F. G. J. Tijl, C. U. Blank, M. C. Burgmans, E. Kapiteijn
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Trials
Subjects:
Advanced uveal melanoma
Percutaneous hepatic perfusion
Immunotherapy
Liver metastases
Online Access:https://doi.org/10.1186/s13063-022-06036-y

Internet

https://doi.org/10.1186/s13063-022-06036-y

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