Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes

Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes

Cytolytic T cell responses are predicted to be biased towards membrane proteins. The peptide-binding grooves of most alleles of histocompatibility complex class I (MHC-I) are relatively hydrophobic, therefore peptide fragments derived from human transmembrane helices (TMHs) are predicted to be prese...

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Bibliographic Details
Main Authors: Richèl J. C. Bilderbeek, Maksim V. Baranov, Geert van den Bogaart, Frans Bianchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
antigen presentation
membrane proteins
adaptive immunity
transmembrane domain
epitopes
MHC-I
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763044/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.763044/full

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