Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD

Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD

Increased lipid bioavailability in a diet favors lipid accumulation, enhancing hepatic lipotoxicity and contributing to insulin resistance (IR) development. The aim of our study was to examine time-dependent alterations in the intrahepatic content of sphingolipids and insulin signaling pathway in ra...

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Bibliographic Details
Main Authors: Klaudia Sztolsztener, Karolina Konstantynowicz-Nowicka, Ewa Harasim-Symbor, Adrian Chabowski
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
insulin signaling
insulin resistance
sphingolipid
lipid accumulation
high-fat diet
Online Access:https://www.mdpi.com/1422-0067/22/22/12478

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https://www.mdpi.com/1422-0067/22/22/12478

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