Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-CellsSummary

Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-CellsSummary

Background & Aims: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circulating GLP-1, the current therapies do no...

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Bibliographic Details
Main Authors: Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
GLP-1
L-Cells
HIF-2α
GPR40
Nutrient-Sensing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2100254X

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http://www.sciencedirect.com/science/article/pii/S2352345X2100254X

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