Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure

Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure

Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β,...

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Bibliographic Details
Main Authors: Jing Long, Yan Huang, Gang Wang, Zhengshan Tang, Yali Shan, Shiping Shen, Xin Ni
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
glucocorticoids
preeclampsia
placenta
mitochondria
ROS
IUGR
Online Access:https://www.mdpi.com/2076-3921/12/5/987

Internet

https://www.mdpi.com/2076-3921/12/5/987

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