Targeting SLC22A5 fosters mitophagy inhibition-mediated macrophage immunity against septic acute kidney injury upon CD47-SIRPα axis blockade

Targeting SLC22A5 fosters mitophagy inhibition-mediated macrophage immunity against septic acute kidney injury upon CD47-SIRPα axis blockade

Efferocytosis of apoptotic neutrophils (PMNs) by macrophages is helpful for inflammation resolution and injury repair, but the role of efferocytosis in intrinsic nature of macrophages during septic acute kidney injury (AKI) remains unknown. Here we report that CD47 and signal regulatory protein alph...

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Bibliographic Details
Main Authors: Yu Jia, Jun-Hua Li, Bang-Chuan Hu, Xia Huang, Xi Yang, Yan-Yan Liu, Juan-Juan Cai, Xue Yang, Jun-Mei Lai, Ye Shen, Jing-Quan Liu, Hai-Ping Zhu, Xiang-Ming Ye, Shi-Jing Mo
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
Macrophage immune
Solute carrier family 22 member 5
Mitophagy
Septic acute kidney injury
CD47-Signal regulatory protein alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024028226

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http://www.sciencedirect.com/science/article/pii/S2405844024028226

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