Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome

Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome

Abstract Pathological cardiac hypertrophy is an important cause of heart failure(HF). Recent studies reveal that glucagon-like peptide-1 receptor (GLP1R) agonists can improve mortality and left ventricular ejection fraction in the patients with type 2 diabetes and HF. The present study aims to inves...

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Bibliographic Details
Main Authors: Wenxiu He, Jiahe Wei, Xing Liu, Zhongyin Zhang, Rongjie Huang, Zhiyuan Jiang
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Glucagon-like peptide-1 receptor agonist
Semaglutide
Pressure overload
Cardiac hypertrophy
Mitophagy
NLRP3 inflammasome
Online Access:https://doi.org/10.1038/s41598-024-62465-6

Internet

https://doi.org/10.1038/s41598-024-62465-6

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