Identification of Phytoconstituents as Potent Inhibitors of Casein Kinase-1 Alpha Using Virtual Screening and Molecular Dynamics Simulations

Identification of Phytoconstituents as Potent Inhibitors of Casein Kinase-1 Alpha Using Virtual Screening and Molecular Dynamics Simulations

Casein kinase-1 alpha (CK1α) is a multifunctional protein kinase that belongs to the serine/threonine kinases of the CK1α family. It is involved in various signaling pathways associated with chromosome segregation, cell metabolism, cell cycle progression, apoptosis, autophagy, etc. It has been known...

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Bibliographic Details
Main Authors: Alaa Shafie, Shama Khan, Zehra, Taj Mohammad, Farah Anjum, Gulam Mustafa Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
casein kinase-1 alpha
phytoconstituents
drug discovery
virtual screening
molecular dynamics simulation
dynamical cross-correlation matrices
Online Access:https://www.mdpi.com/1999-4923/13/12/2157

Internet

https://www.mdpi.com/1999-4923/13/12/2157

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