GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression

GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression

Abstract Background Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds TSPO to enable in vivo visualization and quantification of neuroinfla...

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Bibliographic Details
Main Authors: Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang, Skye Hsin-Hsien Yeh
Format: Article
Language:English
Published: SpringerOpen 2021-03-01
Series:EJNMMI Research
Subjects:
[18F]FEPPA
Neuroinflammation
TSPO
Animal PET
MR imaging
Online Access:https://doi.org/10.1186/s13550-021-00768-9

Internet

https://doi.org/10.1186/s13550-021-00768-9

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