Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway

Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway

Antidepressant fluoxetine can affect cerebral glucose metabolism in clinic, but the underlying molecular mechanism remains poorly understood. Here, we examined the effect of fluoxetine on brain regional glucose metabolism in a rat model of depression induced by repeated corticosterone injection, and...

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Bibliographic Details
Main Authors: Shu-Man Pan, Yi-Fan Zhou, Na Zuo, Rui-Qing Jiao, Ling-Dong Kong, Ying Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
fluoxetine
astrocyte
glycolysis
GR
TXNIP-GLUT1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.872375/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.872375/full

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