DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS).

DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS).

Whole-genome bisulfite sequencing (WGBS) and reduced representation bisulfite sequencing (RRBS) are widely used for measuring DNA methylation levels on a genome-wide scale. Both methods have limitations: WGBS is expensive and prohibitive for most large-scale projects; RRBS only interrogates 6-12% of...

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Bibliographic Details
Main Authors: Giancarlo Bonora, Liudmilla Rubbi, Marco Morselli, Feiyang Ma, Constantinos Chronis, Kathrin Plath, Matteo Pellegrini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214368

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https://doi.org/10.1371/journal.pone.0214368

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