Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis

Background: Acute kidney injury (AKI) occurs in approximately 7–18% of all hospitalizations, but there are currently no effective drug therapy for preventing AKI or delaying its progression to chronic kidney disease (CKD). Recent studies have shown that Scutellaria baicalensis, a traditional Chinese...

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Bibliographic Details
Main Authors: Mengying Yao, Shaozong Qin, Jiachuan Xiong, Wang Xin, Xu Guan, Shuiqin Gong, Jing Chen, Yong Liu, Bo Zhang, Jinghong Zhao, Yinghui Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
oroxylin A
acute kidney injury
mitochondrial energy metabolism
BNIP3
PPARα
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.935937/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.935937/full

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