Low abundance of mitophagy markers is associated with reactive oxygen species overproduction in cows with fatty liver and causes reactive oxygen species overproduction and lipid accumulation in calf hepatocytes

Low abundance of mitophagy markers is associated with reactive oxygen species overproduction in cows with fatty liver and causes reactive oxygen species overproduction and lipid accumulation in calf hepatocytes

ABSTRACT: Mitochondria are the main site of fatty acid oxidation and reactive oxygen species (ROS) formation. Damaged or dysfunctional mitochondria induce oxidative stress and increase the risk of lipid accumulation. During the process of mitophagy, PTEN induced kinase 1 (PINK1) accumulates on damag...

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Bibliographic Details
Main Authors: Zhiyuan Fang, Guowen Liu, Mengyao Zhu, Shu Wang, Qianming Jiang, Juan J. Loor, Hao Yu, Xue Hao, Meng Chen, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Xiliang Du, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Dairy Science
Subjects:
autophagy
hepatocyte
mitochondria
transition period
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030222003976

Internet

http://www.sciencedirect.com/science/article/pii/S0022030222003976

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