From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Abstract The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the close functional ties between mGluR5 and E/I signalling, no-one has directly examined the relationship between mG...

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Bibliographic Details
Main Authors: Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02143-1

Internet

https://doi.org/10.1038/s41398-022-02143-1

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