Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress

Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress

Abstract Background The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology of manganese (Mn)-induced neurotoxicity. Sodium para-aminosalicylic acid (PAS-Na) has a positive effect on the treatment of manganism. Howe...

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Bibliographic Details
Main Authors: Dongjie Peng, Junyan Li, Yue Deng, Xiaojuan Zhu, Lin Zhao, Yuwen Zhang, Zhaocong Li, Shiyan Ou, Shaojun Li, Yueming Jiang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Mn
PAS-Na
Oxidative stress
NLRP3 inflammasome
pyroptosis
NF-κB pathway
Online Access:http://link.springer.com/article/10.1186/s12974-020-02018-6

Internet

http://link.springer.com/article/10.1186/s12974-020-02018-6

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