PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool

PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool

Summary: Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species. Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse...

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Bibliographic Details
Main Authors: Yen-Wei Chen, Graciel Diamante, Jessica Ding, Thien Xuan Nghiem, Jessica Yang, Sung-Min Ha, Peter Cohn, Douglas Arneson, Montgomery Blencowe, Jennifer Garcia, Nima Zaghari, Paul Patel, Xia Yang
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Bioinformatics
Biocomputational method
Systems biology
In silico biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222003224

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222003224

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