Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

The circadian clock regulates diverse physiological processes by maintaining a 24-h gene expression pattern. Genetic and environmental cues that disrupt normal clock rhythms can lead to cancer, yet the extent to which this effect is controlled by the cancer cells versus non-malignant cells in the tu...

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Bibliographic Details
Main Authors: Lee Shaashua, Shimrit Mayer, Chen Lior, Hagar Lavon, Alexander Novoselsky, Ruth Scherz-Shouval
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
circadian clock
Per2
tumor microenvironment
colon cancer
chronobiology
metastasis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.587697/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.587697/full

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