Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients

Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients

Introduction The current guidelines strongly recommend early initiation of multiple classes of cardioprotective drugs for patients with heart failure with reduced ejection fraction to improve prognosis and health status. However, evidence on the optimal sequencing of approved drugs is scarce, highli...

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Main Authors: Yohei Numasawa, Ikuko Ueda, Shun Kohsaka, Yasuyuki Shiraishi, Takashi Kohno, Toshikazu Tanaka, Nobuhiro Ikemura, Makoto Takei, Mitsuyoshi Urashima, Shintaro Nakano, Yuji Nagatomo, Takenori Ikoma, Tomohiko Ono, Munehisa Sakamoto, Kei Nishikawa, Daihiko Hakuno, Ryo Nakamaru
Format: Article
Language:English
Published: BMJ Publishing Group 2024-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/2/e076519.full

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https://bmjopen.bmj.com/content/14/2/e076519.full

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