Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrat...

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Bibliographic Details
Main Authors: Chuanjiang Dong, Jingxuan Zhou, Peng Wang, Tao Li, Ying Zhao, Xiaoyuan Ren, Jun Lu, Jun Wang, Arne Holmgren, Lili Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
ebselen
thioredoxin reductase
topical treatment
Staphylococcus aureus
curcumin
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03016/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.03016/full

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