An update on anticancer drug development and delivery targeting carbonic anhydrase IX

An update on anticancer drug development and delivery targeting carbonic anhydrase IX

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tum...

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Bibliographic Details
Main Authors: Justina Kazokaitė, Ashok Aspatwar, Seppo Parkkila, Daumantas Matulis
Format: Article
Language:English
Published: PeerJ Inc. 2017-11-01
Series:PeerJ
Subjects:
CA IX monoclonal antibodies
Hypoxic tumors
CA IX antitumor agents
Carbonic anhydrase IX
Drug development
Conjugated probes
Online Access:https://peerj.com/articles/4068.pdf

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https://peerj.com/articles/4068.pdf

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