An update on anticancer drug development and delivery targeting carbonic anhydrase IX
The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tum...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2017-11-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/4068.pdf |
| _version_ | 1797418359710547968 |
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| author | Justina Kazokaitė Ashok Aspatwar Seppo Parkkila Daumantas Matulis |
| author_facet | Justina Kazokaitė Ashok Aspatwar Seppo Parkkila Daumantas Matulis |
| author_sort | Justina Kazokaitė |
| collection | DOAJ |
| description | The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis. Thus, the development of potent antitumor drugs targeting CA IX with minimal toxic effects is important for the target-specific tumor therapy. Recently, several promising antitumor agents against CA IX have been developed to treat certain types of cancers in combination with radiation and chemotherapy. Here we review the inhibition of CA IX by small molecule compounds and monoclonal antibodies. The methods of enzymatic assays, biophysical methods, animal models including zebrafish and Xenopus oocytes, and techniques of diagnostic imaging to detect hypoxic tumors using CA IX-targeted conjugates are discussed with the aim to overview the recent progress related to novel therapeutic agents that target CA IX in hypoxic tumors. |
| first_indexed | 2024-03-09T06:31:39Z |
| format | Article |
| id | doaj.art-02e7df40e3034906a538ad77fd8d858f |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:31:39Z |
| publishDate | 2017-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-02e7df40e3034906a538ad77fd8d858f2023-12-03T11:03:35ZengPeerJ Inc.PeerJ2167-83592017-11-015e406810.7717/peerj.4068An update on anticancer drug development and delivery targeting carbonic anhydrase IXJustina Kazokaitė0Ashok Aspatwar1Seppo Parkkila2Daumantas Matulis3Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius University, Vilnius, LithuaniaFaculty of Medicine and Life sciences, University of Tampere, Tampere, FinlandFaculty of Medicine and Life sciences, University of Tampere, Tampere, FinlandDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius University, Vilnius, LithuaniaThe expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis. Thus, the development of potent antitumor drugs targeting CA IX with minimal toxic effects is important for the target-specific tumor therapy. Recently, several promising antitumor agents against CA IX have been developed to treat certain types of cancers in combination with radiation and chemotherapy. Here we review the inhibition of CA IX by small molecule compounds and monoclonal antibodies. The methods of enzymatic assays, biophysical methods, animal models including zebrafish and Xenopus oocytes, and techniques of diagnostic imaging to detect hypoxic tumors using CA IX-targeted conjugates are discussed with the aim to overview the recent progress related to novel therapeutic agents that target CA IX in hypoxic tumors.https://peerj.com/articles/4068.pdfCA IX monoclonal antibodiesHypoxic tumorsCA IX antitumor agentsCarbonic anhydrase IXDrug developmentConjugated probes |
| spellingShingle | Justina Kazokaitė Ashok Aspatwar Seppo Parkkila Daumantas Matulis An update on anticancer drug development and delivery targeting carbonic anhydrase IX PeerJ CA IX monoclonal antibodies Hypoxic tumors CA IX antitumor agents Carbonic anhydrase IX Drug development Conjugated probes |
| title | An update on anticancer drug development and delivery targeting carbonic anhydrase IX |
| title_full | An update on anticancer drug development and delivery targeting carbonic anhydrase IX |
| title_fullStr | An update on anticancer drug development and delivery targeting carbonic anhydrase IX |
| title_full_unstemmed | An update on anticancer drug development and delivery targeting carbonic anhydrase IX |
| title_short | An update on anticancer drug development and delivery targeting carbonic anhydrase IX |
| title_sort | update on anticancer drug development and delivery targeting carbonic anhydrase ix |
| topic | CA IX monoclonal antibodies Hypoxic tumors CA IX antitumor agents Carbonic anhydrase IX Drug development Conjugated probes |
| url | https://peerj.com/articles/4068.pdf |
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