Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.

Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.

Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 of Schizosaccha...

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Bibliographic Details
Main Authors: Sudhir Kumar Rai, Maya Sangesland, Michael Lee, Caroline Esnault, Yujin Cui, Atreyi Ghatak Chatterjee, Henry L Levin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5741268?pdf=render

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http://europepmc.org/articles/PMC5741268?pdf=render

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