Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 of Schizosaccha...
Main Authors: | Sudhir Kumar Rai, Maya Sangesland, Michael Lee, Caroline Esnault, Yujin Cui, Atreyi Ghatak Chatterjee, Henry L Levin |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-12-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5741268?pdf=render |
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