Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution...

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Bibliographic Details
Main Authors: Narayanaiah Cheedarla, Babu Hemalatha, Brahmaiah Anangi, Kannan Muthuramalingam, Murugesan Selvachithiram, Pattabiraman Sathyamurthi, Nandagopal Kailasam, Raghavan Varadarajan, Soumya Swaminathan, Srikanth Prasad Tripathy, S. Kalyanaraman Vaniambadi, D. Ramanathan Vadakkupattu, Luke Elizabeth Hanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus type 1
broadly neutralizing antibodies
Indian HIV-1 subtype C infection
evolution of neutralization response
CD4-binding site
glycan-dependent neutralization
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00618/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00618/full

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