Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains
Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00618/full |
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| author | Narayanaiah Cheedarla Babu Hemalatha Brahmaiah Anangi Kannan Muthuramalingam Murugesan Selvachithiram Pattabiraman Sathyamurthi Nandagopal Kailasam Raghavan Varadarajan Soumya Swaminathan Srikanth Prasad Tripathy S. Kalyanaraman Vaniambadi D. Ramanathan Vadakkupattu Luke Elizabeth Hanna |
| author_facet | Narayanaiah Cheedarla Babu Hemalatha Brahmaiah Anangi Kannan Muthuramalingam Murugesan Selvachithiram Pattabiraman Sathyamurthi Nandagopal Kailasam Raghavan Varadarajan Soumya Swaminathan Srikanth Prasad Tripathy S. Kalyanaraman Vaniambadi D. Ramanathan Vadakkupattu Luke Elizabeth Hanna |
| author_sort | Narayanaiah Cheedarla |
| collection | DOAJ |
| description | Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN) ability (1). In the present study, we report our findings on the evolution of host bNAb response over a period of 4 years in a subset of these individuals. Three of the five individuals (NAB033, NAB059, and NAB065) demonstrated a significant increase (p < 0.05) in potency. Interestingly, two of the three samples also showed a significant increase in CD4 binding site-specific antibody response, maintained stable CD4+ T cell counts (>350 cells/mm3) and continued to remain ART-naïve for more than 10 years after initial diagnosis, implying a strong clinical correlation with the development and evolution of broadly neutralizing antibody response against HIV-1. |
| first_indexed | 2024-12-14T00:03:05Z |
| format | Article |
| id | doaj.art-02ec40529aa24a7f93eebeab3b09316b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T00:03:05Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-02ec40529aa24a7f93eebeab3b09316b2022-12-21T23:26:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-03-01910.3389/fimmu.2018.00618318531Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 StrainsNarayanaiah Cheedarla0Babu Hemalatha1Brahmaiah Anangi2Kannan Muthuramalingam3Murugesan Selvachithiram4Pattabiraman Sathyamurthi5Nandagopal Kailasam6Raghavan Varadarajan7Soumya Swaminathan8Srikanth Prasad Tripathy9S. Kalyanaraman Vaniambadi10D. Ramanathan Vadakkupattu11Luke Elizabeth Hanna12Department of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaMolecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaART Center, Kilpauk Medical College and Hospital, Chennai, IndiaMolecular Biophysics Unit, Indian Institute of Science, Bangalore, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaAdvanced Bioscience Laboratories Inc., Rockville, MD, United StatesDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, IndiaStrain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN) ability (1). In the present study, we report our findings on the evolution of host bNAb response over a period of 4 years in a subset of these individuals. Three of the five individuals (NAB033, NAB059, and NAB065) demonstrated a significant increase (p < 0.05) in potency. Interestingly, two of the three samples also showed a significant increase in CD4 binding site-specific antibody response, maintained stable CD4+ T cell counts (>350 cells/mm3) and continued to remain ART-naïve for more than 10 years after initial diagnosis, implying a strong clinical correlation with the development and evolution of broadly neutralizing antibody response against HIV-1.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00618/fullhuman immunodeficiency virus type 1broadly neutralizing antibodiesIndian HIV-1 subtype C infectionevolution of neutralization responseCD4-binding siteglycan-dependent neutralization |
| spellingShingle | Narayanaiah Cheedarla Babu Hemalatha Brahmaiah Anangi Kannan Muthuramalingam Murugesan Selvachithiram Pattabiraman Sathyamurthi Nandagopal Kailasam Raghavan Varadarajan Soumya Swaminathan Srikanth Prasad Tripathy S. Kalyanaraman Vaniambadi D. Ramanathan Vadakkupattu Luke Elizabeth Hanna Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains Frontiers in Immunology human immunodeficiency virus type 1 broadly neutralizing antibodies Indian HIV-1 subtype C infection evolution of neutralization response CD4-binding site glycan-dependent neutralization |
| title | Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains |
| title_full | Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains |
| title_fullStr | Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains |
| title_full_unstemmed | Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains |
| title_short | Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains |
| title_sort | evolution of neutralization response in hiv 1 subtype c infected individuals exhibiting broad cross clade neutralization of hiv 1 strains |
| topic | human immunodeficiency virus type 1 broadly neutralizing antibodies Indian HIV-1 subtype C infection evolution of neutralization response CD4-binding site glycan-dependent neutralization |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00618/full |
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