Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia

Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia

Background: Acute myeloid leukemia (AML) is the malignant proliferation of immature myeloid cells characterized by a block in differentiation. As such, novel therapeutic strategies to promote the differentiation of immature myeloid cells have been successful in AML, although these agents are targete...

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Bibliographic Details
Main Authors: Sydney Fobare, Ola A. Elgamal, Mark Wunderlich, Emily Stahl, Abeera Mehmood, Casie Furby, James R. Lerma, Thomas M. Sesterhenn, Jianmin Pan, Jayesh Rai, Megan E. Johnstone, Amina Abdul-Aziz, Mariah L. Johnson, Shesh N. Rai, John C. Byrd, Erin Hertlein
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
EZH2
acute myeloid leukemia
differentiation therapy
Online Access:https://www.mdpi.com/2072-6694/16/3/569

Internet

https://www.mdpi.com/2072-6694/16/3/569

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