GDF-8 improves in vitro implantation and cryo-tolerance by stimulating the ALK5-SMAD2/3 signaling in bovine IVF embryo development

GDF-8 improves in vitro implantation and cryo-tolerance by stimulating the ALK5-SMAD2/3 signaling in bovine IVF embryo development

Transforming growth factor-beta (TGF-β) plays a critical role in regulating trophoblast invasion and proliferation. Growth differentiation factor-8 (GDF-8) is a member of the TGF-β superfamily and is categorized as a myostatin subtype. It is primarily a secreted protein synthesized in skeletal muscl...

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Bibliographic Details
Main Authors: Seon-Min Kang, Muhammad Idrees, Chalani Dilshani Perera, Seo-Hyun Lee, Mingjun Zhang, Xianfeng Yu, Yongxun Jin, Il-Keun Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GDF-8
ALK5-SMAD2/3 signaling
embryo development
in vitro implantation
cryotolerance
bovine
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1345669/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1345669/full

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