Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors

Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty-two of the 24 COEs synthesized, except <b>COE-17</b> and <b>COE-24</b>, had potent and/or significant s...

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Bibliographic Details
Main Authors: Jong Min Oh, T. M. Rangarajan, Reeta Chaudhary, Rishi Pal Singh, Manjula Singh, Raj Pal Singh, Anna Rita Tondo, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
monoamine oxidase
acetylcholinesterase
chalcones
oximes
kinetics
reversibility
Online Access:https://www.mdpi.com/1420-3049/25/10/2356

Internet

https://www.mdpi.com/1420-3049/25/10/2356

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